N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester

  • Name: N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester
  • CAS: 1256490-31-9
  • Purity: 99%
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Quality products?make an important contribution to long-term revenue and profitability. Cosmetics Grade N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester 1256490-31-9 For Sale with Good Price

1.What is the N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester ?

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

p-nitrophenyl phenyl phosphorochloridate
793-10-2

p-nitrophenyl phenyl phosphorochloridate

alanine isopropyl ester hydrochloride
39613-92-8,62062-56-0,62062-65-1

alanine isopropyl ester hydrochloride

(S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester
1256490-31-9

(S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

Conditions
Conditions Yield
p-nitrophenyl phenyl phosphorochloridate; alanine isopropyl ester hydrochloride; In dichloromethane; at 0 ℃; for 0.25h; Industrial scale;
With triethylamine; In dichloromethane; at 0 ℃; for 1h; Industrial scale;
32%
4-nitro-phenol
100-02-7,78813-13-5,89830-32-0

4-nitro-phenol

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

alanine isopropyl ester hydrochloride
39613-92-8,62062-56-0,62062-65-1

alanine isopropyl ester hydrochloride

(S)-2-[(R)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester
1256490-49-9

(S)-2-[(R)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

(S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester
1256490-31-9

(S)-2-[(S)-(4-nitro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester

Conditions
Conditions Yield
O-phenyl phosphorodichloridate; alanine isopropyl ester hydrochloride; With triethylamine; In dichloromethane; at -10 - -3 ℃; for 0.25h;
4-nitro-phenol; With triethylamine; In dichloromethane; at 20 ℃; Cooling;
O-phenyl phosphorodichloridate; alanine isopropyl ester hydrochloride; With triethylamine; In dichloromethane; at -60 - -50 ℃;
4-nitro-phenol; In dichloromethane; at -60 - 20 ℃;
155 g

2.What is the CAS number for N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester ?

The CAS number of N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester is 1256490-31-9.

More information of N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester 1256490-31-9 are:

CAS?Number

1256490-31-9

Density

1.302

Melting Point

62-66℃

Boiling Point

514.3±60.0 °C(Predicted)

PSA

129.49000

LogP

5.00450

Pka

-5.78±0.70(Predicted)

3.What are another words for N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester ?

Synonyms?for?N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester 1256490-31-9:N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester;L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester;2. N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine;N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl este;isopropyl((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-L-alaninate;(S)-Isopropyl 2-(((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate

4.What is the molecular formula of N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester?

The chemical formula of ?N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester is?C18H21N2O7P which containing 18 Carbon atoms,21 Hydrogen atoms,2 Nitrogen atoms,7 Oxygen atoms and 1 Phosphorus atoms,and the molecular weight of??N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester?is 408.348.

5.What is N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester (1256490-31-9) used for?

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester is a complex organic compound that serves as a crucial intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), an impurity of PSI-7977 (P839640). N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester plays a significant role in the development of antiviral agents, particularly for the treatment of hepatitis C.

Relevant articles related to N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester:

Article

Source

PROCESS FOR THE PREPARATION OF (Sp)-SOFOSBUVIR AND INTERMEDIATES THEREOF

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Page/Page column 11, (2018/03/28)

DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER

-

Page/Page column 52; 53, (2016/03/22)

6.Buy N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester with the best price .

Hebei Road biotechnology co., LTD is a quality supplier of N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester 1256490-31-9.

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