L-A-HYDROXYGLUTARIC ACID DISODIUM)

  • Name: L-A-HYDROXYGLUTARIC ACID DISODIUM)
  • CAS: 63512-50-5
  • Purity: 99%
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Quality products?make an important contribution to long-term revenue and profitability. High Quality Chinese Manufacturer supply 63512-50-5 L-A-HYDROXYGLUTARIC ACID DISODIUM)

1.What is the L-A-HYDROXYGLUTARIC ACID DISODIUM) ?

L-α-Hydroxyglutaric acid disodium salt is suitable for use in collection buffer for increased recovery of hypoxia-inducible factor-1 α (HIF-1α), a marker of hypoxia in human tumors. It is also suitable for the radiolabeled 5mC-5hmC conversion assay to study the effect of 2-HG on the TET family of methyl hydroxylases.

L-glutamic acid
56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6

L-glutamic acid

(S)-2-hydroxypentanedioic acid, disodium salt
40951-21-1,55714-86-8,63512-50-5,103404-90-6

(S)-2-hydroxypentanedioic acid, disodium salt

Conditions
Conditions Yield
L-glutamic acid; With potassium nitrite; sulfuric acid; In water; at -10 ℃;
With sodium hydroxide; Further stages.;
62%
(2S)-tetrahydro-5-oxofuran-2-carboxylic acid
21461-84-7

(2S)-tetrahydro-5-oxofuran-2-carboxylic acid

(S)-2-hydroxypentanedioic acid, disodium salt
40951-21-1,55714-86-8,63512-50-5,103404-90-6

(S)-2-hydroxypentanedioic acid, disodium salt

Conditions
Conditions Yield
With sodium hydroxide; In water; at 25 ℃; for 2h; pH=10;
31.43%

2.What is the CAS number for L-A-HYDROXYGLUTARIC ACID DISODIUM) ?

The CAS number of L-A-HYDROXYGLUTARIC ACID DISODIUM) is 63512-50-5.

More information of L-A-HYDROXYGLUTARIC ACID DISODIUM) 63512-50-5 are:

CAS?Number

63512-50-5

Melting Point

>300°C

PSA

100.49000

LogP

-3.37270

3.What are another words for L-A-HYDROXYGLUTARIC ACID DISODIUM) ?

Synonyms?for?L-A-HYDROXYGLUTARIC ACID DISODIUM) 63512-50-5:L-alpha-Hydroxyglutaric acid, disodium salt;(S)-2-Hydroxypentanedioic acid;L-α-Hydroxyglutaric acid disodium salt;(2S)-2-Hydroxyglutaric acid disodium salt;Pentanedioic acid, 2-hydroxy-, disodium salt, (S)- (9CI);

4.What is the molecular formula of L-A-HYDROXYGLUTARIC ACID DISODIUM)?

The chemical formula of ?L-A-HYDROXYGLUTARIC ACID DISODIUM) is?C5 H6 O5 *2Na which containing 5 Carbon atoms,6 Hydrogen atoms,1 Oxygen atoms and 1 Sodium atoms,and the molecular weight of??L-A-HYDROXYGLUTARIC ACID DISODIUM)?is 192.079.

5.What is L-A-HYDROXYGLUTARIC ACID DISODIUM) (63512-50-5) used for?

L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.

InChI:InChI=1/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1

Relevant articles related to L-A-HYDROXYGLUTARIC ACID DISODIUM):

Article

Source

Pteridines Part CXVIII. Methanopterin, chemical approach and partial synthesis

Heizmann, Gerhard,Pfleiderer, Wolfgang

, p. 1856 - 1873 (2008/03/12)

6.Buy L-A-HYDROXYGLUTARIC ACID DISODIUM) with the best price .

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