MK-2206 2HCl

  • Name: MK-2206 2HCl
  • CAS: 1032350-13-2
  • Purity: 99%
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Details

Buy cost-effective 99% pure MK-2206 2HCl 1032350-13-2 now

  • Molecular Formula: C25H21N5O*2ClH
  • Molecular Weight: 480.397
  • PSA： 89.07000 
  • LogP: 6.54700 

1032350-13-2 Relevant articles

IL-23 ANTAGONISTS FOR TREATMENT OR PREVENTION OF SKIN RASH ASSOCIATED WITH TREATMENT WITH P13K/AKT PATHWAY INHIBITORS

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Paragraph 00186; 00187, (2013/03/26)

The present invention provides methods f...

1032350-13-2 Process route

tert-butyl {1-[4-(3-oxo-9-phenyl-2,3-dihydro[1,2,4]triazolo[3,4-f][1,6]naphthyridin-8-yl)phenyl]cyclobutyl}carbamate

tert-butyl {1-[4-(3-oxo-9-phenyl-2,3-dihydro[1,2,4]triazolo[3,4-f][1,6]naphthyridin-8-yl)phenyl]cyclobutyl}carbamate

MK-2206
1032350-13-2

MK-2206

Conditions
Conditions Yield
tert-butyl {1-[4-(3-oxo-9-phenyl-2,3-dihydro[1,2,4]triazolo[3,4-f][1,6]naphthyridin-8-yl)phenyl]cyclobutyl}carbamate; With hydrogenchloride; In ethanol; water; at 50 ℃; for 3h;
With acetyl chloride; In ethanol; at 0 - 20 ℃; for 1.5h;
tert-butyl (2-chloro-3-formylpyridin-4-yl)carbamate
893423-62-6

tert-butyl (2-chloro-3-formylpyridin-4-yl)carbamate

MK-2206
1032350-13-2

MK-2206

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1.1: trifluoroacetic acid / dichloromethane / 20 - 35 °C / Cooling
2.1: potassium hydroxide / isopropyl alcohol / 1 h / 24 °C
3.1: hydrogenchloride / isopropyl alcohol / 16 h / 66 - 70 °C / Cooling
4.1: hydrogenchloride / water; ethanol / 3 h / 50 °C
4.2: 1.5 h / 0 - 20 °C
With hydrogenchloride; trifluoroacetic acid; potassium hydroxide; In ethanol; dichloromethane; water; isopropyl alcohol;

1032350-13-2 Upstream products

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    4-amino-2-chloronicotinaldehyde

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