What is the (R)-(+)-1,2-Dithiolane-3-pentanoic acid?

(R)-(+)-1,2-Dithiolane-3-pentanoic acid is yellow crystalline solid, while it's Molecular Formula is C8H14O2S2. yellow crystalline solid a-Lipoic acid has been used as a reference standard for the analysis of a-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS). It may be used as a reference standard for the determination of a-lipoic acid in human urine by isocratic reversed-phase HPLC and in a-lipoic acid capsules by HPLC with chemiluminescence detection.

What is the CAS number for (R)-(+)-1,2-Dithiolane-3-pentanoic acid?

The CAS number of (R)-(+)-1,2-Dithiolane-3-pentanoic acid is 1200-22-2.

What is the (R)-(+)-1,2-Dithiolane-3-pentanoic acid?

(R)-(+)-1,2-Dithiolane-3-pentanoic acid is yellow crystalline solid, while it's Molecular Formula is C8H14O2S2. yellow crystalline solid α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS). It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection.

What is the CAS number for (R)-(+)-1,2-Dithiolane-3-pentanoic acid?

The CAS number of (R)-(+)-1,2-Dithiolane-3-pentanoic acid is 1200-22-2.

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Product classification

(R)-(+)-1,2-Dithiolane-3-pentanoic acid

Name: (R)-(+)-1,2-Dithiolane-3-pentanoic acid
CAS: 1200-22-2
Purity: 99%

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Details

Bulk supply high purity (R)-(+)-1,2-Dithiolane-3-pentanoic acid 1200-22-2, Paid sample available

Molecular Formula: C8H14O2S2
Molecular Weight: 206.33
Appearance/Colour: yellow crystalline solid
Melting Point: 48-52 °C(lit.)
Refractive Index: 114 ° (C=1, EtOH)
Boiling Point: 362.5 °C at 760 mmHg
PKA: 5.4(at 25℃)
Flash Point: 173 °C
PSA： 87.90000
Density: 1.218 g/cm³
LogP: 2.78510

(R)-(+)-1,2-Dithiolane-3-pentanoic acid(Cas 1200-22-2) Usage

General Description

α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms.

Biochem/physiol Actions

(R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease.

InChI:InChI=1/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1

1200-22-2 Relevant articles

Enantioselective Synthesis of R-(+)-α-Lipoic Acid

Page, Philip C. Bulman,Rayner, Christopher M.,Sutherland, Ian O.

, p. 1408 - 1409 (1986)

The title compound has been synthesised ...

ASYMMETRIC SYNTHESIS VIA ACETAL TEMPLATES. 12. HIGHLY DIASTEREOSELECTIVE COUPLING REACTIONS WITH A KETENE ACETAL. AN EFFICIENT, ASYMMETRIC SYNTHESIS OF R-(+)-α-LIPOIC ACID.

Elliott, John D.,Steele, John,Johnson, William S.

, p. 2535 - 2538 (1985)

TiCl4 catalyzes the essentially quantita...

Coevolution of the Activity and Thermostability of an ?-Keto Ester Reductase for Better Synthesis of an (R)-α-Lipoic Acid Precursor

Chen, Qi,Xu, Jian-He,Xu, Yao,Zhang, Zhi-Jun,Zheng, Gao-Wei

, (2019)

In this work, we have identified a signi...

Stereocontrolled reactions induced by a thermolabile group. Synthesis of optically active 1,3-diols

Bloch, Robert,Bortolussi, Michel,Girard, Christian,Seck, Matar

, p. 453 - 462 (1992)

Wittig Horner-Michael reactions of phosp...

Microwave-assisted resolution of α-lipoic acid catalyzed by an ionic liquid co-lyophilized lipase

Liu, Ning,Wang, Lei,Wang, Zhi,Jiang, Liyan,Wu, Zhuofu,Yue, Hong,Xie, Xiaona

, p. 9949 - 9960 (2015)

The combination of the ionic liquid co-l...

Preparation method of R-lipoic acid

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Paragraph 0039; 0065-0067; 0085-0087; 0105-0106, (2021/07/31)

The invention discloses a preparation me...

Synthesis method R -lipoic acid

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Paragraph 0042; 0070-0074; 0094-0096; 0116-0117, (2021/09/26)

A synthesis method of R -lipoic acid com...

Preparation method of R-lipoic acid tromethamine salt

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Paragraph 0028; 0036; 0038; 0045; 0047; 0054, (2021/05/12)

The invention relates to a preparation m...

Preparation method of D-lipoic acid

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Paragraph 0040-0070, (2021/02/24)